Yes. Trial and error for now. Let the screw touch the carto and then count how many times you turn to make a small hole. Also check to be sure that you've gone all the way through the outside wall of the carto. Use a needle to be sure the fuller is exposed and that the juice will feed into it. For a small hole I suggest a second hole on the other side of the carto. If you decide to go with one hole and you have trouble getting it to feed, a neat trick is to give the e-cig a few good hard draws without pressing the firing button. That will draw juice into the carto.
Now I see why they call you, "Super Member".
Thanks for the valuable tip.