"While further research is needed to fully understand the effects of e-cigarette exposure in humans in vivo, we caution against the widely held opinion that e-cigarettes are safe."
I agree with this statement. This study looks decent to me in terms of its methodology, especially compared to many other studies into vaping. E-cigarettes are not "safe" - they are waaaaaaay safer than cigarettes, which are themselves way safer than jumping into lava. The problem is that being way safer leads to them being erroneously labelled as safe by many proponents, whereas never-smokers who start vaping do show signs of worsening quality breathing. For those of us that switched from smoking cigarettes they're great and the number of awful studies claiming otherwise have led many people to immediately dismiss any study suggesting harm from vaping, which I don't think is helpful for anyone.
I would have liked for them to test 100% VG and 100% PG separately rather than just 50:50 and whilst 36mg/ml nic may seem excessive it is the top end of what I've heard of people using. Furthermore, using straight-up eliquid and condensate rather than vapour will obviously result in far more prolonged exposure than vaping ever produces, but this makes it easier to see what problems may arise from repetitive exposure to vapour over the course of a few decades.
@Myk TNFa modulates immune function in many ways - it can induce cell death but also stimulates the production of many inflammatory cytokines. Obviously in your case the predominant effect is undesirable (as a matter of fact, every time it was mentioned as a druggable target during my studies the goal was reducing/inhibiting its effects) but if a person with normal physiology took your medicines...well, they wouldn't have a good time
Calling it pro- or anti-inflammatory is an oversimplification that many journal articles are guilty of and news outlets are even worse :/
Mucolytics in aerosols have been trialed with CF and COPD but with more side-effects than positive effects, but my messiah complex with regards to drugging myself up says that I could probably titrate a dose for myself as an eliquid component to finally put an end to coughing up mucus...
I agree with this statement. This study looks decent to me in terms of its methodology, especially compared to many other studies into vaping. E-cigarettes are not "safe" - they are waaaaaaay safer than cigarettes, which are themselves way safer than jumping into lava. The problem is that being way safer leads to them being erroneously labelled as safe by many proponents, whereas never-smokers who start vaping do show signs of worsening quality breathing. For those of us that switched from smoking cigarettes they're great and the number of awful studies claiming otherwise have led many people to immediately dismiss any study suggesting harm from vaping, which I don't think is helpful for anyone.
I would have liked for them to test 100% VG and 100% PG separately rather than just 50:50 and whilst 36mg/ml nic may seem excessive it is the top end of what I've heard of people using. Furthermore, using straight-up eliquid and condensate rather than vapour will obviously result in far more prolonged exposure than vaping ever produces, but this makes it easier to see what problems may arise from repetitive exposure to vapour over the course of a few decades.
@Myk TNFa modulates immune function in many ways - it can induce cell death but also stimulates the production of many inflammatory cytokines. Obviously in your case the predominant effect is undesirable (as a matter of fact, every time it was mentioned as a druggable target during my studies the goal was reducing/inhibiting its effects) but if a person with normal physiology took your medicines...well, they wouldn't have a good time
Calling it pro- or anti-inflammatory is an oversimplification that many journal articles are guilty of and news outlets are even worse :/Mucolytics in aerosols have been trialed with CF and COPD but with more side-effects than positive effects, but my messiah complex with regards to drugging myself up says that I could probably titrate a dose for myself as an eliquid component to finally put an end to coughing up mucus...
