I do get an off taste with nichrome, it's like a hint of sucking on a penny. Also, nichrome seems softer than kanthal, so not quite as easy to build with, and I always had issues with wraps shorting on eachother, so it had to be torched before and after wrapping. Some of that could have been me, I haven't used it since my early rebuilding days.
Have you tried Ni wire Lessifer and if so, did you get the same flavor effect?