I would say the reason to use this over an Ego and Cartomizer or clearomizer would be consistency, capacity and ruggedness.
The bottle squeezing is not the power mechanism. The bottle squeezing is to wet the filler of a cartomizer or the wick of an atomizer. While clearomizers may work on a REO they kind of defeat the purpose of a bottom-feeder as your juice supply is held in the self-contain plastic bottle within this device. The REO and Woodvils also have power buttons just like the Ego. As a matter of fact, I recommend Egos to anyone who is getting started since they aren’t really sure whether this technology is for them and if they really want to make a larger investment or not. I too found switching flavors appealed to me for a time. However after nearly a year and a half I found that I liked coffee vapes with my coffee in the morning, I liked fruity vapes during the day and then a cocktail type vape in the evening to go with a tall rum & coke after dinner.
The REO lets me fill a 3ml or 6ml bottle that contain about 3 to 6 times the amount of e-liquid you can get into a clearomizer and simply squeeze the bottle anytime the coil of the atomizing devices gets a little dry. Oh and I've never heard of any juices making a plastic bottle crack ever. You would typically tilt you clearomizer to get the wicks wet but you have to refill you clearomizer many more times than I do before my bottle runs empty. Additionally, you EGO contains a proprietary battery ranging from 650mah to 1000mah that cost 3-5 times as much as the batteries recommended for the REO and these general purpose batteries handle varying loads much better than an EGO if you delve into a low-resistance offerings. Additionally the REO metal mods are wireless and have been reported to have been driven over by a truck without failure continuing to work as expected. The metal versions can even be put into the dishwasher for cleaning(with battery and atomizing devices removed) without issue. That sums up ruggedness.
For consistency, when I used the clearomizers, the vape changed as I worked through the day. The juice began turning dark almost immediately. As the juice level dropped the Ego needed to be tipped or shaken to get the wicks wet enough to transfer to the coil. This involved jumping through hoops over a period of 2-3 hours. A reo grand with two full 6ml bottles , a fresh 18650 battery and a fresh atomizer will get me through nearly 4 full days away from home with only a single bottle change and a couple battery charges/changes. I typically get over 12 hours from a IMR 18650 1600mah battery and can get almost 18 waking hours from an 18650 2200mah protected battery using a LR 2.0 Ohm atomizer or cartimizer.
I do not work for Rob in any capacity but I have recently stayed at a Holiday Inn Express. I hope this helps. Brew