I kinda rest the button against the inside of my ring finger, or my picky, grasp and tighten my grip. I was wary about getting a bottom button mech, but decide to just go ahead and buy one anyway. Since then, I've learned two things:
1) it's pretty ergonomic, and isn't awkward like I thought
2) the bottom button is the simplest activation design. It's hard to mess up a bottom button, since it's just a pin that you push up to make contact with the battery. Any kind of side button requires a lot more design, and parts to make it work correctly, which will lead to a lot more maintenance in many cases.
So, for me, I've grown to love the bottom button for practical, as well as aesthetic reasons.