Caffiene + Nicotine =

[vapdivrr]

My - A copy/paste from a post on an open forum

"Caffeine and nicotine are different in their actions as stimulants. Caffeine is a non selective methyl xanthine phosphodiesterase inhibitor that serves to increase intracellular cAMP (a second messenger). When cAMP is elevated, cells become more excitable. There are two primary second messenger molecules, cAMP and cGMP. cAMP is more prevalent in neurons that lead to behavioral (and brain) excitation (dopamine, norepinepherine, epinephrine, etc), although it is also found in monoamine neurons that are associated with behavioral depression and sleep (e.g., serotonin). So, the stimulant action one sees from caffeine is largely due to hyper-excitation in the excitatory neurons neurons. The reason caffeine causes sleeplessness is because it is acting on the same systems affected by amphetamine and [blow], except with a much lesser overall effect.

Nicotine is a nicotinic acetylcholine agonist. That is, it acts directly on acetylcholine nicotinic receptors where it mimics the effects of acetylcholine. The preponderance of nicotinic receptors are contained in the peripheral nervous system. It is nicotinic stimulation that causes contraction of striate muscles that allow for body movement. The nicotinic receptors on the blood vessels cause constriction. In the brain, nicotinic cholinergic receptors are involved in learning and memory, concentration, and many other processes. The stimulant effects one sees from nicotine is largely due to its net effect on brain systems. It is not a behavioral stimulant the way caffeine is. In fact, nicotine has both activating and sedating properties, but the activation is much less behavioral in nature. The reason that it doesn't interfere with sleep is because of that.

I didn't intend to make this a pharmacology lesson."

Oh, I totally understand now

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[vapdivrr]

So can one buy a bottle of straight caffeine like you can with nicotine? Like different strenghts?

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[Rossum]

So can one buy a bottle of straight caffeine like you can with nicotine? Like different strenghts?

Pure caffeine is a solid, a white powdery substance. It was possible to buy it until recently, but I've heard the FDA has cracked down on it.

FWIW, when I was in high school in the 1970s, one experiment we did in advanced chemistry was to determine the concentration of caffeine in tea leaves by extracting it from 1/4 lb thereof. We got less than a teaspoon full of it, but it was quite potent.

 

[SlowTalker]

 

[JSL_Aus]

This cat ain't anxious

 

[vapdivrr]

Pure caffeine is a solid, a white powdery substance. It was possible to buy it until recently, but I've heard the FDA has cracked down on it.

FWIW, when I was in high school in the 1970s, one experiment we did in advanced chemistry was to determine the concentration of caffeine in tea leaves by extracting it from 1/4 lb thereof. We got less than a teaspoon full of it, but it was quite potent.

Thanks, never knew that....

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[Johnny2Vapes]

HUGE anxiety attack this morning! I was vaping on my endura t18 with some 12mg juice and drinking my coffee then all of a sudden BAM massive anxiety shot right through me. I had to wind up getting up and doing some dishes to get myself calmed down. Anyone else experience this or just a fluke?

Caffiene and Nicotine are both stimulants. Anxiety is caused by other factors in life, mostly deep rooted ones. I'm not a MD but I can assure you that mixing a stimulant while also under an overactive brain can be problematic. I'd advise you to speak to your GP if you have one.