CBD what is it and how to use ?

[Cool_Breeze]

I've been using a 1000 mg concentrated isolate in 50/50 PG/VG which I then dilute out to 330 mg with no flavoring.
I was using a WPC (whole plant cannabinoid) oil orally but I found it took too long to take effect and was prohibitively expensive. I switched to a vapable isolate as it it MUCH faster acting AND much cheaper.
I suffer from chronic back pain and insomnia, CBD is a great medication for both these conditions.
My daughter suffers from insomnia and CFS ME, I treat her symptoms with CBD now too with some success.

@sonicbomb - I'm not clear on just what quantities, etc. you are using. I'd have to guess, I guess to know how much PG/VG liquid the 1000 mg went into. I.e., how many milligrams per milliter was your mix and how much do you consume per day or per session?

Could you also define 'vapable isolate?'

I'm pleased to know it works for you!

 

[Cool_Breeze]

I buy it pre-mixed with PG and VG and then dilute it to about 330 mg.
I vape it with an rda.
Dosage in individual, I usually take four or five hits and hold it down for a while.

'How much' premixed PG/VG (ml) do you mix the 330 mg of CBD into?

 

[Izan]

More info: not a light read.
https://www.hindawi.com/journals/bmri/2018/1691428/

cheers
I

 

[Cool_Breeze]

It seems there is a lot of investment money flying around CBD/Hemp and related realms. Consider the economies in places where recreational use is supported by state laws. Regarding CBD itself, I suspect that a lot of funds are spent on 'marketing.'

Weigh what you read about CBD very carefully, understand the terms used and the context.

 

[sonicbomb]

how much PG/VG liquid the 1000 mg went into

10 ml, follow the link to my vendor in my first post
CBD Shot - 1000mg

Could you also define 'vapable isolate?'

Again, read the page on the vendors site I linked to -
"CBD products can take a number of forms, some with more than one type of cannabinoid (as in Broad-Spectrum Oil) and some using an Isolate form of CBD, as used in our LiQuid CBD e-liquids. CBD Isolate is a pure form of CBD which is added to our e-liquid blends as a crystalline powder.
It all begins with the hemp plant. The plant material undergoes an initial extraction process which turns it into full-spectrum oil, which contains a range of synergistic cannabinoids, lipids (fats) and waxes naturally found in the plant. It is then further refined using a patented distillation process all the way down to a single crystallised CBD molecule. Using this method, we’re able to verify 99.9% purity, with absolutely zero THC or any other unwanted cannabinoids or chemicals. This leaves us with an incredibly pure, tasteless CBD powder which is the ideal match for our e-liquids."

'How much' premixed PG/VG (ml) do you mix the 330 mg of CBD into?

The product is 10 ml 50/50 VG/PG 1000 mg, I mix it with 20 ml 50/50 VG/PG resulting in 30 ml at 333.33 mg recurring. A 1 to 3 ratio.

 

[sonicbomb]

@Izan because science

CBD: Ability to Cross Blood-Brain Barrier Opens Up New Treatment Options | Inverse

Blood–brain barrier - Wikipedia

I also read another interesting article which I can't find now.
It suggested that the anti-psychotic quantities of CBD balance out the negative aspects of THC, in effect nature balancing itself chemically.
The issue being that modern super strong cannabis strains intentionally push THC levels to unsafe levels that the body cannot effectively metabolise causing a progressive build up in the body. These same breeding techniques dramatically reduce the CBD levels that might mitigate the negative effects of these THC concentrations.

 

[Cool_Breeze]

@sonicbomb - Appology offered. While had visited that site, I didn't gather details there and seemingly lost the context inbetween posts. It now appears to me that you are vaping ~33mg/ml (CBD) liquid and perhaps no nicotine in that. Great that it takes you only a few draws held in to deal with your pain.
What I'm currently using is 33mg/ml or thereabouts. Perhaps I should reconsider full-time use of that. I had seen figures in the realm of 50mg daily total and that's about where I'm at. Of course that level varies with the type of pain.

 

[sonicbomb]

you are vaping ~33mg/ml (CBD) liquid and perhaps no nicotine in that.

Yes. You can see on the labelling it says 10%. 1 gram dissolved in 10 ml.
In terms of dose it's obviously an individual thing. The reason I shot for the 300 mg level was that I had used the flavoured 300 mg product and found that worked. Buying the concentrate and diluting it is more cost effective, and also means I can remove flavouring from the equation. My one criticism of their products generally is that they are too heavily flavoured, including their nicotine juices.

10 ml @ 300 mg - £7
30 ml @333 mg - £15

It's not advised to go above 50% VG in your mix as it becomes cloudy. I did one mix with 70% VG and it turned to a crystalline snot and was unusable.

 

[englishmick]

I got a bottle from Hemplucid that comes in all VG. It was like you described, thick, cloudy, and green, and I couldn't vape it, even diluted with a load of PG.

The one I have now, Koi brand isolate, comes in PG/VG. They don't give the ratio. It's clear and quite thin. Great vape.

Wizard sells it in all PG, full spectrum. I want to try that. I've read several times that full spectrum gives better results with smaller amounts than isolate because of the cocktail of different components.

I've also read that CBD dissolves better in PG than in VG. Like pretty much everything else I've read I don't know if that's true or not.

 

[Fog n Vape]

So far I feel there is good information sharing on this thread and so far the moderators have left us alone so we haven't crossed any invisible lines.

So quick update from Dr. appointment today. The two concerns I had regarding CBD use was interaction with blood thinners and possible interferance with liver processing.
Good timing Dr. said as the results from my latest blood work was in both from her request and latest cancer specialist request. She doesn't see any issue with CBD for me as liver function has been monitored and shows no issues. The same for aspirn, no issue there either as her understanding is that that possible interaction is with actual blood thinners whereas aspirn while used as a blood thinner it's more of a side effect associated with aspirn though there may be an issue if I was on warfarin , not sure of the spelling, type of actual blood thinners.

She has no concerns about my vaping CBD as she said I've been getting CBD in the Cannabis I use and if there was going to be any complications it would have shown up by now with the amount of blood work I have done on a regular basis.
She did ask that when/if I pursue buying isolate and mixing that I keep track of dosage and let her know what amount seems to work for me as she has had quite a few patients asking about CBD and she would like some real world information on theraputic levels.
I showed her the 3rd party testing results from company I'm considering buying from and she was pleased that I was taking steps to insure quaility control in suppliments I may use.

I've had a legal exemption to grow and use Cannabis for around 17 years and won that right in a court case around 2003, it's so long ago now I'd have to dig out the court files to remember the actual dates.
I have no business connection to the Cannabis industry in any way meaning I don't sell cannabis and am not involved in any way with the black market underground economy.

My aim after having a major brain stem stroke in 1999 was to get healthy enough to return to performing and recording music. That took 10 years and Cannabis was instrumental in dealing with the complications of stroke , I spent 6 months using a walker and another 2 years with cane before I could walk without a cane. My avatar photo was taken performing at a Celtic music festival just a few months before the cancer diagnosis ended my music performing/recording career for the 2nd time due to medical reasons.

Cannabis is a wonderfuĺl medicine and has been a huge part of my healing journey both from stroke and recently stage 4 cancer.

I don't have a medical degree and don't know all the scientific terms that some do but in my case I know that Cannabis has enriched and helped my life more than any prescription poison.

There is a principle that will condem mankind to eternal ignorance and that is Contempt before Investigation

Just to let everyone know that I'm not some stoner trying to get a buzzzzzzz.

 

[sonicbomb]

As far as I know all modern medicines originate from nature even if they are now synthesised.

 

[Cool_Breeze]

@sonicbomb - Without rereading all, I recall that you are using your mix with 4 or 5 draws to ease your back pain. Calculation leads me to understand that your mix is about 33 mg CBD / ml.

For how long does that ease your pain? Do you then take a few more draws? I'm trying to understand the frequency of your use.

 

[Fog n Vape]

https://www.tandfonline.com/doi/abs/10.1080/14786419.2019.1663515?journalCode=gnpl20
The above link is a research paper entitled "Comparrision of Cannabis Sativa using different extraction and concentration methods "

Pubmed is a wonderfuĺl informative resource. When I search CBD get 6,674 references to research papers.

So if anyone says CBD is not well researched the above fact usually shuts them up quickly.

I use pubmed all the time to research any medicines, supplements or diagnosis. Drives my G.P. crazy at times but hey that's why she gets the big bucks, to put up with patients like me

Home - PubMed - NCBI

 

[sonicbomb]

For how long does that ease your pain? Do you then take a few more draws?

It takes a couple of minutes to take effect, pain relief lasts for 2-3 hours. If my pain is more severe I may double or even triple this dose.

 

[stratus.vaping]

I've been vaping CBD and making tea from flowers for some years. Only Swiss grown or Colorado organic with full lab reports. Helps with my pain and inflamation tremendously.

Edit - I should add that care should be taken with the source of isolate particularly, there is a lot of contaminated stuff around, likely produced in China or some mud hut somewhere. I've seen lab reports that would make your hair curl ... I don't like consuming solvent residue.

Seem to be questions about dose and frequency, the simple answer is whatever gives you the result you need. It's a very personal thing.

 

[Fog n Vape]

Bioavailability of CBD Varies Depending on Route of Administration

Found a few articles on absorption rate differences pertaining to delivery methods.
This one is from a retailer of cbd products but they provide links to the research papers their article is based on, which addresses the concern, somewhat, of bias.

 

[sonicbomb]

From the above article -

The averages for CBD bioavailability by method of administration are:

• 6% - 15% for oral (swallowed and digested by the GI system)
• 35% for oromucosal (absorbed directly through the mouth)
• 34%-46% for intranasal (applied through the nose)
• 40% for vaporized (absorbed through the lungs)

 

[Cool_Breeze]

I've revisited my 33mg (CBD) /ml mix. Despite my previous postings, I suggest that continual vaping at that level may not be a grand idea.

 

[Fog n Vape]

From the above article -

The averages for CBD bioavailability by method of administration are:

• 6% - 15% for oral (swallowed and digested by the GI system)
• 35% for oromucosal (absorbed directly through the mouth)
• 34%-46% for intranasal (applied through the nose)
• 40% for vaporized (absorbed through the lungs)

....guess I should have done a synopsis of article as not everyone has time to read links.
Ty
Earl

 

[Cool_Breeze]

I too tested at 33mg/ml as that is 1 gram isolate into 30 ml PG/VG
I found it too harsh to vape and set it aside.
So, where did you find your level? Or did you?

I arrived at 33mg(CBD)/ml by reading 'somewhere' that 50mg/day was an appropriate level of CBD for relieveing some type of pain. I vape about 1 1/2 ml/day. I routinely vape 50mg/ml of nicotine in VG, so I'm used to a strong vape. The 33mg of CBD in with the 50mg nicotine made some difference, but not a huge amount in throat/mouth feel. My reasons for not doing that as an all day thing were matters other than throat sensation.

In your case it might seem ever stronger per PG.