I arrived at 33mg(CBD)/ml by reading 'somewhere' that 50mg/day was an appropriate level of CBD for relieveing some type of pain. I vape about 1 1/2 ml/day. I routinely vape 50mg/ml of nicotine in VG, so I'm used to a strong vape. The 33mg of CBD in with the 50mg nicotine made some difference, but not a huge amount in throat/mouth feel. My reasons for not doing that as an all day thing were matters other than throat sensation. In your case it might seem ever stronger per PG.