Nope, the ones in the holder are empty, washed out, ready to refill. Once a week I take the ones needing cleaning to the sink, spend 5mins or so cleaning them, blowing them out til dry then sit them in the holder. The mouth end caps are in a freezer bag cleaned too. I have them in the holder battery end down

If you fill them and sit them in the holder then you wanna sit them mouthpiece end down with cap on to keep the
juice near the wick.
Any I have filled I sit in the plastic things they come in, mouthpiece end down.