I know some members are concerned about the ingredients in the flavorings, which ones are safe or safer, and which ones are known to be a concern.
Another member took the time to compile information for quick reference to these materials (and credit goes to RocketPuppy for doing this - thank you!):
The chemicals that are in some flavorings that are of concern are Diacetyl, Acetyl Propionyl, and Acetoin.
"There are more than 2,000 substances used in flavoring manufacturing. The FDA regulates flavorings to ensure they are safe when eaten. Many flavorings have been in longstanding use and are classified by the FDA as "Generally Recognized as Safe" (GRAS) to eat. Thus far, the FDA does not require testing for other routes of exposure, such as inhalation. Though with new regulations, this will change in time.
Some flavoring manufacturers are using alternative substances for diacetyl in formulating flavorings. These compounds are acetoin and acetyl propionyl. Like diacetyl, these are 'GRAS' substances that are approved for use in food. Their chemical structures are very similar to diacetyl and have been found to be equally as harmful for inhalation."
Companies are not required to report if their flavorings contain less than 1% of diacetyl or diacetyl substitutes (
https://www.dir.ca.gov/title8/5197.html).
Two companies (FA and TFA) have shown that in using a flavoring at less than 0.5%, 1000s of ppbs have been found, yet NIOSH recommends the exposure limit (REL) for vapor inhalation up to 8-31 ppb.
CDC - Flavorings-Related Lung Disease: Exposures to Flavoring Chemicals - NIOSH Workplace Safety and Health Topic
https://www.osha.gov/dts/shib/shib10142010.html
http://www.perfumerflavorist.com/fla...aign=Most+Read
FA, or FlavourArt is heading a project aimed at reducing the risk of harm reduction for smokers and reduction of these chemicals in flavorings:
Diacetyl | ClearStream by FlavourArt
FA has an e-cigarette flavoring specific line:
http://flavourartexpress.biz/index.p...category_id=15
TFA/TPA, or The Flavor Apprentice/The Perfumers Apprentice (same company), provides a list of their flavoring ingredients:
Perfumer's Apprentice
Perfumer's Apprentice
This is a thread here where a member has compiled a list of TFA flavors that do not contain the ingredients known to be of risk - see post #1:
http://www.e-cigarette-forum.com/forum/diy-e-liquid/554391-my-tfas-choice-list.html
There are 2 ingredients that flavor manufacturers have used as a substitute to diketones - Acetyl propionyl and acetoin. This is a statement made by TFA about these two ingredients in their line of flavorings (It also explains the differences in these 2 ingredients):
http://shop.perfumersapprentice.com/...p/custard.html
Additional information:
IJERPH | Free Full-Text | Impact of Flavour Variability on Electronic Cigarette Use Experience: An Internet Survey
Safety Assessment and Regulatory Authority to Use Flavors: Focus on E-Cigarettes | FEMA
Recent study on e-liquids and the quantity of those known chemicals:
http://gfn.net.co/downloads/2014/pos...0- DA_AP.pdf
A different perspective questioning the validity of concern for Diacetyl (diketones and their derivatives) based on studies that only accounted for workers who had a smoking history (which most of us as vapers do):
Diacetyl and 2,3-pentanedione exposures ...... [Crit Rev Toxicol. 2014] - PubMed - NCBI