I started with Greensmoke, in vanilla at 0mg. Later started using 6mg. Even at that, I started getting TH that I was missing. I still had the 0mg carts tho, so switched back and forth a lot for a while.
My opinion is yes, nicotine content does affect TH, but I've also found only a slight difference between, say 6mg and 12mg. I finally settled on 18mg because the TH was too much for me at 24mg, but YMMV. I found all that to be true, too, for cartos, cartridges, direct dripping and the tank.