Yea, mesh is generally set it and forget it. Real trick is to get the roll diameter just right to be a snug fit through the coil and then to use a VV battery on lowest setting to test fire for hot spot, wiggle the coils until they set where they're happy, and you're good to go.
No need to change or clean it, almost ever, since once one juice is cycled through, the mesh retains no leftover flavor and the next juice will have its proper and full taste.