I used to be a pack-and-a-half a day smoker with Marlboro reds. I get a bit of 24 mg nic on my hands every day. I don't Immediately run to a sink, but rubbing it off on my jeans seems to work ok! Like it was said earlier, it all depends on your nic level. I had a friend react badly to a bottle that spilled on her, but it turned out she couldn't handle that level. All just depends on your tolerance!