The 2 biggest worries with nicotine are contamination and oxidation. Contamination can be controlled by limiting the amount of time that the nic solution is exposed to, well, anything. Just keep it in a well sealed bottle and only open the bottle when you need to. Oxidation can be controlled by limiting the amount of air that is in the bottle, as oplholik stated. Freezing, or even refrigerating the nic, will slow the oxidation reaction, as lower temps slow most chemical reactions. Also, oxidation isn't really bad for nic. All it does it make the nic turn yellow, as well as reduce the potency of the nic. Oxidation will not affect the flavor of the nic, whereas contamination will, depending on the contaminant. Keep your nic stored in glass bottles so that there is no chance of plastic leeching into the nic.