Anything can be toxic to a child or animal that is ok for an adult in limited form - aspirin, any medicines in fact, coffee, any kind of stimulant inc alcohol and many other items. It HAS to be marked TOXIC so people without a brain cell dont start putting it on the cat's dinner and then say 'oh but how was I to know..' It also covers the supplier and manufacturer in case of an accident; they warned you, you ignored it kind of deal.
Most chemicals can be toxic in large amounts, nicotine is no different even though it is a naturally occurring one - so is belladonna and that stuff will lay you out

Keep it under lock n key or so high up even a goat would have an issue reaching it.
Take the proper precautions if you handle the raw stuff and you should be fine; chemists handle it all the time without ill effect, as they take it seriously. As for vaping it, its safe enough in the tiny doses used in eliquids - I believe cigs contain a lot.
Just use your normal caution if you're DIYing with high strength.
Btw, Ive spilled the ready made stuff on me more times than I can count, got it in my mouth, licked the end of my PV (yeah..well..it tasted nice..lol), got it in my eye once by accident (that wasn't pleasant at all thank god for eye drops and irrigation), and Im still here typing using both eyes and all my fingers.