IMO, leaving a battery for a couple of days at 20% or about 3.5V at rest is slightly easier on it than leaving it at 100% or about 4.2 V for a couple of days. I use a set of 4 batts for daily
vaping. I cycle
through them in order by using one until it goes down to 3.6 - 3.7V or about 35%, then replace it. I charge a pair when I have about half a day remaining on the last one. This way the fully charged time is between 1/2 and 1 1/2 days after charging and any batts that are waiting for charge are at 3.7'ish.
I believe leaving a battery to rest for a few hours after use is better than not doing that. Letting them rest for at least a few hours after charge is also good. I have no idea how much difference it makes.
I have a couple of times discharged down to 2.5V by mistake and then I immediately charge it at least partially. This is with hybrids like the VTC series, LG HE2 and Samsung 25R that are rated down to 2.5V. I believe that is really hard on them though and any less than 2.5V will hurt them and become a safety risk.
I have a few
batteries that I don't use often. I leave them at 3.7-3.8V until I need one.