I think the temperature of the vape makes a big difference, too.
LR, SR, bottom coil, top coil, more volts, more watts...it's all very subjective.
But, for me, nicotine definitely amplifies the TH.
My go-to flavor is a Vanilla 24mg, but last time I was at the store they only had 12mg...same taste, NO throat hit.
I won't be making that mistake again.