I'd say it makes a world of a difference for me as a newbie. I am still trying to find what juices I prefer and what PG/VG ratio i like. If I stuck with one e-liquid it may not matter, but I have some liquids that on lower voltages, I get almost no flavor. On the other side of the spectrum, I have some flavors that taste fine on a higher votage but the throat hit is unbearable for me. It really all seems to come down to what works for the individual, but VV, for me, has definitely been great.