I started at 36. My body was quick to tell me that was too much. I then started mixing two flavors that both had 21, or one was 21 and the other was 10. The ratio of the mix yielded 18 or 19 if I used the 21 and 10. I'm now vaping a 24mg/ml liquid, that will go down to a high 22 low 23 if I use one or two flavors with it. I don't see any change in the future, but my crystal ball gets a little too foggy sometimes..