If I have a 30A battery should I be aiming to stay in the 20-25A range? How much of a buffer should I leave between the battery's suggested CDR and what amperage I'll have with my build?
There is no typical round cell that, when fully charged to 4.2 volts, can deliver 4.2 volts to the coil build in a single battery mech excepting only if the coil build in question has such a huge resistance that it would be impossible to get any vapor out of it. Due to the DC internal resistance of the battery, there will be voltage sag so the volts delivered to the coil build in a single battery mech will be 4.2 volts
minus the voltage sag. So, by entering 4.2 volts into the Ohm's Law equation, there is already a buffer having been already factored in, conveniently, for those looking to switch from a regulated mod to a mech (single battery mech, that is).
This isn't to say you can't add an extra buffer for additional safety. You most certainly can. But the recommended starting point, i.e., always recommended by Mooch for those who ask "How much is safe?", is to stay at or below the true CDR, which, to be real accurate, is the CDR reported by Mooch in his battery test results, of the battery you select for vaping. Finally, I highly recommend that you watch Mooch's videos on his personal YouTube channel, where he goes by the name of Battery Mooch. There's several episodes going into further related specifics about battery safety including for mech users. For example, Ep02 of
Minding Your mAhs videos covers this particular topic for mech users.