I am a heavy vapor and go through 2 2900 mAh 18650s while at work with a LR306 atty. If I switched to 6v, stacking 2 500 mAh 3v LiFePO4 batteries, I would go through 24 of them for the same amount of vaping! No way I am going to do that when I am happy with 3.7v @ 1.5ohms. Even if it were a bit better, it would not be worth the hassle.
Not necessarily true, since you would not be using a 1.5ohm atty at 6v. You would most likely use a much higher ohm atty like 3.0ohm or even higher, drastically decreasing the drain on the batteries.
I vape HV constantly and rarely go thru 2 full sets of IMR 18650 batteries in a day using 4.5ohm attys.
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