I know that the screen can be upside down for the lefties. I figured that out by holding it in my left hand. But thats only if you use your thumb to press the firing button, and then turn it horizontally and turn it right. But like, its not that big of an extra step to just turn it left and push up the bottom instead? Just use your pointer, middle, ring, or pinky to press the firing button, and then when you need to change the screen, turn it right and its not upside down...IDK. I'm trying to figure out how it could possibly be that big of a problem. I wouldn't give a flying frog if the screen were "upside down" for righties. I don't think its upside down for lefties... I don't think the screen COULD BE upside down period lol. Do you really want the 1st number to be on the bottom when your looking at it strait on? In both hands, there are not more extra steps for lefties than there are for righties from my trials.
Anyway, I haven't put mine down either. Its my workhorse for now.