It depends a lot on your juice. I can use the same build on my Oddy with clear clean juices for over a week, but with my NET tobaccos I have to dry burn after a tank full. The same will happen with dark sweet juices also. All I have to do is take it apart, soak the rebuildable unit in hot tap water for about 5 mins, pat it dry and dry burn and clean and ready for use again. I can clean and dry burn 4-6 times, but because materials are cheap, I just re-do it as often as I like.
Its a give or take, with Genesis, there is more work to making your coil and wick with the Silica types like Odysseus rebuilding takes a few minutes. With good silica you can reuse it a few times even if it gets really crusty. Just torch it.
Because Im a heavy vaporer, I have an extra rebuildable unit and base so I can have one ready to go. With my clear lighter, or fruity juice I can refill and refill for over a week before the taste changes or vapour declines. This might seem like a lot of cleaning, but it beats having to use and toss 4 cartomizers a day to enjoy my delicious tobaccos.
Funny though, in my experience with talking to others who use Genesis, they usually tend to use lighter fruity flavours. I havent met any one that uses Genesis and real tobacco (NET). I wonder how many Genesis users vape naturally extracted tobaccos and how it fairs.
I tried a few high end Genesis atomizers with my NETs and the taste changed way too much, too harsh for me.