Study on rats inhaling nicotine...interesting find.

[420GypsyGirl]

The Department of Medicine, University Hospital, Tronheim, Norway, found:

“tobacco smoking has been reported to be associated with increased risk of cardiovascular disease and cancer, particularly of the lungs. In spite of extensive research on the health effects of tobacco smoking, the substances in tobacco smoke exerting these negative health effects are not completely known. Nicotine is the substance giving the subjective pleasure of smoking as well as inducing addiction. For the first time we report the effect on the rat of long-term (two years) inhalation of nicotine. The rats breathed in a chamber with nicotine at a concentration giving twice the plasma concentration found in heavy smokers. Nicotine was given for 20 h a day, five days a week during a two-year period. We could not find any increase in mortality, in atherosclerosis or frequency of tumors in these rats compared with controls. Particularly, there was no microscopic or macroscopic lung tumors nor any increase in pulmonary neuroendocrine cells. Throughout the study, however, the body weight of the nicotine exposed rats was reduced as compared with controls. In conclusion, our study does not indicate any harmful effect of nicotine when given in its pure form by inhalation.”

I also learned some things about PG in that hospitals actually vape it and add Triclosan to the air to help kill air borne bacteria! Yes that is right. They have vaporizors in their air ducts that vape PG and Triclosan to kill bacteria in the air and this is all EPA and FDA approved!

 

[Kimmberlee]

The Department of Medicine, University Hospital, Tronheim, Norway, found:

“Tobacco smoking has been reported to be associated with increased risk of cardiovascular disease and cancer, particularly of the lungs. In spite of extensive research on the health effects of tobacco smoking, the substances in tobacco smoke exerting these negative health effects are not completely known. Nicotine is the substance giving the subjective pleasure of smoking as well as inducing addiction. For the first time we report the effect on the rat of long-term (two years) inhalation of nicotine. The rats breathed in a chamber with nicotine at a concentration giving twice the plasma concentration found in heavy smokers. Nicotine was given for 20 h a day, five days a week during a two-year period. We could not find any increase in mortality, in atherosclerosis or frequency of tumors in these rats compared with controls. Particularly, there was no microscopic or macroscopic lung tumors nor any increase in pulmonary neuroendocrine cells. Throughout the study, however, the body weight of the nicotine exposed rats was reduced as compared with controls. In conclusion, our study does not indicate any harmful effect of nicotine when given in its pure form by inhalation.”

I also learned some things about PG in that hospitals actually vape it and add Triclosan to the air to help kill air borne bacteria! Yes that is right. They have vaporizors in their air ducts that vape PG and Triclosan to kill bacteria in the air and this is all EPA and FDA approved!

That is EXTREMELY interesting!!! I love it when I have some data to tell people when they look at me like I have totally LOST my mind for vaping.

Thank you very much for sharing!!!

 

[pianoguy]

If they'd just add some nicotine, we could all just go hang out in the hospital lobby ;-)

 

[DaBrat]

Thanks for that bit of info as most studies I find use nicotine and cigarette smoke interchangably. This puts my mind at ease seeing the nicotine sans 4000+ chemicals in this study.

The PG in the ventilation is one of the reasons for that famous 'hospital smell'

 

[Christina]

Interesting news about the nicotine study! Studies such as that could be helpful down the road in reversing indoor vaping laws... I would hope.

5 days a week? Poor rats must have had a tough time with withdraw on the weekends.

 

[420GypsyGirl]

I also read that the rats that took part in the nicotine study that inhaled the nicotie were healthier in that they never became obese. LOL! The nicotine actually helped controlling their apetites and they were less likely to overeat compared to the control rats that did not inhale nicotine.

Maybe that is why I have a hard time gaining weight. I just don't eat that much.

 

[notsoogood]

I already knew about the hospitals but the nicotine part was really interesting! Thanks for the info! Great find!!!

 

[notsoogood]

I also read that the rats that took part in the nicotine study that inhaled the nicotie were healthier in that they never became obese.

I wish I had that problem

 

[Wireguy]

I'll meet you there!

If they'd just add some nicotine, we could all just go hang out in the hospital lobby ;-)

 

[jlmanno]

great article and information! certainly makes me feel great about quitting analogs and certainly a lot better about vaping, cause I'm definitely a vapaholic, I REALLY enjoy vaping a heck of a lot more than I ever enjoyed smoking!

 

[RatRacer]

I also read that the rats that took part in the nicotine study that inhaled the nicotie were healthier in that they never became obese. LOL! The nicotine actually helped controlling their apetites and they were less likely to overeat compared to the control rats that did not inhale nicotine.

Maybe that is why I have a hard time gaining weight. I just don't eat that much.

Well, that does not seem to be the case in my control group. Now that I've regained my sense of taste, I seem to want to resample everything I've eaten the last 30yrs in about 3 months time.8-o
I've added 10 pounds since I started vaping.

 

[Wafflestomper]

Don't know if these are of interest. Just a few random articles I found floating around. I'm sure this is nothing new to those researching, but just in case..
PG test (nasal inhalation in rats)
Subchronic nose-only inhalation study of propylene... [Food Chem Toxicol. 1989] - PubMed result
PG as a humectant in tobacco
Toxicologic evaluation of humectants added to cigarette tobacco: 13-Week smoke inhalation study of glycerin and propylene glycol in Fischer 344 rats
An article about PG in E-Cigs, I'm pretty sure I saw a similar article posted somewhere on the forums.
Vaporized Propylene Glycol, a Key Ingredient in Electronic Cigarettes, May Prevent Pneumonia, Influenza, and Other Respirator... ( Inhalation o...)
This is one of many MSDS sheets out there. Most of them are pretty similar.
http://www.ppe.com/msds/Propylene glycol.pdf

 

[420GypsyGirl]

A report in Time Magizine about PG and it's health "benefits"! Yes...this is true! PG Testing done in the 1940's and why it is considered safe.

PG Test Article from Time Magazine. << click this link

 

[420GypsyGirl]

Do you realize that PG is in all kinds of products, from soap, to food, to cosmetics, to anti-freeze, to the very air we breath in a lot of buildings because it is used in filtration systems to control bacteria and viruses. And yet the FDA questions it's safety! After being used in products for over 100years... the FDA questions if it is safe to inhale. Test have show it stops harmful airborne viruses like influenza, pnuemonia vey well and that might be why it is heavily used in hospitals to fight bacteria and viruses. Test have shown it also kills the dreaded HN1N flu virus. This could save millions of lives...and yet the FDA questions it's safety.

This goes beyond a safety issue. I think someone or someones do not wish e-cigarettes to become an alternitive to smoking because of the amount of revenue that would be lost. Imagine all the taxes that are generated via tabacco. Now imagine if that suddenly vanished. Also, what about the big tabacco companies and what they may loose in this. Yeah...a lot. Well screw them and screw the FDA. Vape on! Vape for life!

 

[Madame Psychosis]

Do you realize that PG is in all kinds of products, from soap, to food, to cosmetics, to anti-freeze, to the very air we breath in a lot of buildings because it is used in filtration systems to control bacteria and viruses. And yet the FDA questions it's safety!

Well, the FDA is actually concerned about contaminants. (And supposedly, the nitrosamines...hah.hah.hah. You've have to vape liters of nic liquid to get nitrosamine intake close to a few cigarettes.)

But you're right about PG being ubiquitous. Propylene glycol is also commonly used for intravenous delivery of some drugs in hospitals, such as benzodiazepines. There are a handful of reports of PG toxicity when large doses were given IV. Not our concern given the milliliters we're vaping daily.

 

[Kurt]

Very nice find, 420GypsyGirl! Nicotine, perhaps unfortunately, does have many clinically proven benefits. I use it to combat fundamental nerve pain from a nerve illness I have, with great results, and which otherwise would require powerful and dangerous drugs. This was why I smoked in the first place, and now vaping is working even better than analogs for this. Bonus! Plenty of studies showing increased concentration and intelligence too, and they are wanting to use PVs for treatment of Parkinsons. Nic also combats Alzheimers...that's been know for a while now.

But this leads back to my use of the word "unfortunately", as FDA is purposefully distorting facts and plain lying to get ecigs banned, but IMHO this is money talking, as in BP that wants us to get cancer and buy their useless NRTs, and govt that wants tobacco tax money. My opinion, but I have yet to see evidence to the contrary. I don't think common sense and our health is very important to them at all, in fact it seems the opposite is true.

Thanks for posting this!