Characterization of menthol
1) Trends in quantities of menthol present in the cigarette rod and smoke over time for various brands/subbrands of menthol and nonmenthol products as determined by the Cambridge Filter/ISO test method using standard parameters as well as the intense smoking conditions set forth in Canadian regulations.
2) Information regarding the manufacturing of menthol and nonmenthol cigarettes, including a) the source and type of menthol used, b) the presence or use of any menthol analogs, and c) the types of manufacturing processes through which menthol is introduced into the
tobacco product, as well as the considerations in selecting a particular method.
3) The threshold (menthol content) at which a product is identified and marketed as a menthol cigarette and how that threshold is established.
4) The rationale for adding menthol to cigarettes not marketed as menthol cigarettes, and the criteria for determining the quantity of menthol to be added.
5) For international brands of menthol cigarettes, the quantities of menthol in both menthol and nonmenthol cigarettes sold internationally, and the factors considered in determining the quantity of menthol to be added.
Clinical effects of menthol
6) Studies of dose-response relationships for the physiologic effects of mentholated
tobacco smoke.
7) Mechanistic studies of menthol effects including, a) chemosensory effects of menthol compounds in
tobacco smoke, including effects at thermal and trigeminal receptors, b) the effect of menthol on the neurobiology of tobacco dependence, and c) the effect of menthol on clinical and behavioral measures.
8) Studies addressing the dosing relationship and the metabolic interactions between nicotine and menthol, including resulting perceptions of nicotine strength and the interaction between menthol delivery and nicotine/tar levels, for both low-menthol and high-menthol products.
9) Information on correlations between menthol content and consumer perceptions
regarding a) taste, b) nicotine strength, and c) product harm.
Biomarkers
10) Analyses of laboratory and populations studies using biomarkers to assess the effect of menthol content on disease risk for cigarette smokers, based on cigarette consumption (e.g., cigarettes per day), including data related to menthol among population subgroups.
Marketing data
11) Data on consumer preferences for menthol cigarettes.
12) Consumer perception studies of advertising, packaging, and labeling of menthol cigarettes.
13) Marketing strategies for various brands/subbrands of menthol cigarettes, including strategies targeted to particular demographic groups.
14) Marketing strategies for various brands/subbrands of menthol cigarettes sold internationally.
Population effects
15) Among cigarette smokers, rates of switching from menthol to nonmenthol cigarettes and vice versa.
16) Comparative rates of initiation by youth and young adults with menthol and nonmenthol cigarettes.
17) Comparative rates of cessation for users of menthol and nonmenthol cigarettes.