I primarily use tanks on mechanical mods - I think they're a great combination. I only use rebuildables and don't have any experience with these new sub-ohm tanks or Kanger products, but there's no reason why you can't use them. Heck, I used to use cartomizer tanks on mechanical mods before I got into RBAs. The only concern that I can think of, aside from making sure that your battery can handle the resistance of your coil, is making sure that the atomizer's center pin protrudes enough from the 510 connection if using it on a mod with a hybrid connection, but this pertains to any type of atomizer, not just tanks.