Power (Watts) = Volts^2 / Resistance
So, when you use a variable voltage device, you have to figure out your voltage to set your device to a particular coil resistance. For example, if you have a 2.4 Ohm atomizer, then you might like around 4.5 volts. However, if you change your delivery device and it has a different resistance coil, then you have to adjust your voltage up or down depending on the resistance. At first, your just guessing and adjusting until you get a vape you like. After a while, you get an idea where you need to be on the voltage when you put on a different atomizer.
Now, the great thing about variable wattage is that you can find a power setting you like (say 10 Watts for example), and the device will read the Ohms of the atomizer and adjust the voltage. Basically, its doing all the thinking for you. You can switch from a tank to a carto to a dripper, and have three different resistance coils, and get the same vape because the device will adjust the voltage for you.