If switching out the wife isn't an option, there are other options. I don't know where you live, but you could vape outside? You could put in a filtration system down in your lair (heh, we live in Tucson, the land of no basements, my husband misses his "lair) and see if that helped at all.... With something to recirculate the air directly outside, if that's feasible.
Or, indeed, you could try vaping no flavors and see if that helps. I might try that first, and then experiment with small amounts of different flavorings to see which ones the wife may be having problems with. That's going to take some time, and checking out the DIY flavoring board might be helpful to you, as you're probably going to need to try small amounts of different things for a while... Which is actually a great way to build DIY skills.
It is possible for folks to be sensitive to VG or too much PG. I am bad with larger amounts of PG so I use 90% VG and 10% water. It is also possible to be sensitive to VG, in which case you may have to look into filtration options, I'm not certain it's possible to vape only PG (though it very well may be).
This is going to take some experimenting and detective work probably.... Good luck, hope that you can make things work for everyone in the house.
Anna