When you start getting burnt taste, you still have time to go before you need to toss it in trash. More than less vapor production, burnt taste is my ultimate sign that it over. I do consider less vapor to be a sign of battery dying as well.
That little "hint" of hot polyester was my signal to switch cartos. Never managed to burn one badly enough to have to toss it, but then again my taste buds may not be the best. Now, with the CE3 there's never a question about when it's empty.
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