I am on meds for depression.I am also a DIY person.I mixed up 4 OZ of one of my favorite flavors.Vanilla butter nut and I put to much Nic in it.I was vaping it any ways.Just made me a little more hyper but no racing heart or headache.I have been vaping it for over a week and I have noticed that I feel better,have more interest in things,easier to get out and do things.That is the only change I have made.I know Nic helps with depression.Has any one else had this effect from Nic?Hope everyone is having an awesome day A.J