It's doable, but certainly not advised, unless you like picking yourself up off the floor. I was happy at 24mg when starting out with stuff like the Nautilus Mini. Once I started playing with RTAs and RDAs, a drop in nic was definitely required. Now, I am quite happy with 6mg in my Rocket RTA on my Provari 2.5 and Helios RDA or Mutation X V2 RDA on my Nemesis. Still playing with builds and whatnot, but happy with gear and nic for the time being.