I did find a study on PG inhalation that seems to indicate that most of it does not actually reach the lungs (only about 5%) ..but that study was done on people standing in a mist of PG and water and not actually inhaling from a device like we would.
Dr. Eissenberg got a KR808...
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Since you can metabolize other inhaled things wouldn't PG enter the bloodstream the same way as being ingested and be eliminated through the kidneys likewise?
"The route of elimination depends on the dose
administered, not on the route of exposure. It is mainly
excreted in the urine as the glucuronide conjugate but 12-45%
is excreted unchanged (Ruddick, 1972). Renal clearance
decreases with dose (390 mL/min/1.73 m2 at a dose of 5 g/day,
but only 144 mL/min/1.73 m2 at a dose of 21 g/day) (Speth et
al, 1987)."
administered, not on the route of exposure. It is mainly
excreted in the urine as the glucuronide conjugate but 12-45%
is excreted unchanged (Ruddick, 1972). Renal clearance
decreases with dose (390 mL/min/1.73 m2 at a dose of 5 g/day,
but only 144 mL/min/1.73 m2 at a dose of 21 g/day) (Speth et
al, 1987)."
I misquoted here I'll fix that below....
Things seem to indicate that this is true..at least according to the CDC and other studies...
EDIT: According to the CDC's Agency for Toxic Substances & disease Registry:
Absorption of propylene glycol from the gastrointestinal tract is rapid: maximal plasma concentrations in humans occur within 1 hour after ingestion.
Metabolites
Propylene glycol is metabolized in the liver by alcohol dehydrogenase to
•lactic acid, and then
•pyruvic acid
Both of these metabolites are normal constituents of the citric acid cycle and are further metabolized to
•carbon dioxide and
•water
About 45% of an absorbed propylene glycol dose is excreted by the kidneys unchanged or as the glucuronide conjugate.
Half-Life
The elimination half-life of propylene glycol is about 4 hours.
found here: http://www.atsdr.cdc.gov/csem/egpg/propylene_glycol.html
in reguards to my misquote.. the study I was refering to was from a paper by NASA (and it's all Adrenalynn level sciencey) but it makes reference to a study with people in a mist tent of PG and water that's 10% pg...only 5% of that got breathed in and significantly less than that actually made it into the lungs..Here's the quote:
"Because the solubility of PG in water is high, one might expect that any inhaled vapor reaching the lungs would be very well absorbed by the lung and metabolized by the liver in a fashion similar to its metabolism from an ingested dose, although one might expect some quantitative differences. Cavender and Sowinski (1994) described a work in which humans were exposed to 10% PG in a mist tent with labeled deionized water. Less than 5% of the mist entered the body and, of this amount, 90% lodged in the nasopharynx and disappeared in the stomach; very little was found in the lungs. It appears that most of the inhaled PG aerosol becomes trapped in the upper respiratory tract and does not reach the lungs."
Here's the link to the full 14 pages of PG numbers for the super scientifically minded that can interpret NASA's numbers.
Spacecraft Maximum Allowable Concentrations for Selected Airborne Contaminants: Volume 5
"The purpose of this document is to review the existing inhalation toxicology literature on PG and develop maximum acceptable air concentrations for 1 h, 24 h, 7 d, 30 d, 180 d, and 1,000 d of potential exposure to vapors of PG."
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I've added it to my "read later" plugin for FireFox. I'm swamped at this instant, but this is some great stuff you guys are digging up!
There is a lot of mundane and unethical research done in the 40's on it as a vapor but it won't give you the scientific numbers, just the diagnosis of people and animals afterward.
Overall the parent compound PGME is mainly what causes toxicity and not its metabolites. Tests on PGME with people in chambers of the vapor for hours only show signs of eye irritation at low doses and few with throat irritation. At high doses some (3/23) have irritation, headache, and nausea but clinical chemistry and urinalysis completed following exposure was not altered as compared to pre-exposure measurements.
Overall the parent compound PGME is mainly what causes toxicity and not its metabolites. Tests on PGME with people in chambers of the vapor for hours only show signs of eye irritation at low doses and few with throat irritation. At high doses some (3/23) have irritation, headache, and nausea but clinical chemistry and urinalysis completed following exposure was not altered as compared to pre-exposure measurements.
That's the article that I saw, Thor ... whatever's going on, the nicotine delivery is a lot more effective against craving than patches, gum, etc., by all accounts that I can see, not to mention my own still-amazed experience... I really would like to know why that is. Like you Adren, I don't wake up with that urgency... in fact, it never happens. Not a steady state (such as it is) like a patch though... just all very interesting.
Not to sidetrack, but I wasn't familiar with the read it later firefox plugin til you mentioned it. I would just open a tab and leave it till I got to it. So I had 50 tabs open all the time and never got to half of them..... 8-o
Big Thanks!
that is something i was wondering but i wasn't sure if it was a totally ridiculous idea or not.
fetasigma, ty for chiming in!
maxx, knowing will also affect my vaping habits... or perhaps, better put, it'll help me advise people who are interested in vaping. whatever i'm doing personally is working, but i don't know why, or if it's something about my methods or no.
Here's another one written on the parent compound of PG (PROPYLENE GLYCOL MONOMETHYL ETHER), Mr. Vice President.Woot! Another study for my collection!
http://oehha.ca.gov/air/chronic_rels/pdf/107982.pdf
what do you mean, emini?
i have a couple of studies to read that reference the gum/patches but i haven't had a chance yet. maybe joe/'lynn/smarter people than i will be able to understand their significance better but i'll look for any gems.
i have a couple of studies to read that reference the gum/patches but i haven't had a chance yet. maybe joe/'lynn/smarter people than i will be able to understand their significance better but i'll look for any gems.
Very cool, I am trying to find who ordered his for the Dr. cause as far as I know, we are the ONLY seller of cowboy 18.
I had made an offer to supply our products to Dr. E to use
Thanks
Steve
Very cool, I am trying to find who ordered his for the Dr. cause as far as I know, we are the ONLY seller of cowboy 18.
I had made an offer to supply our products to Dr. E to use
Steve, I'm pretty sure that Dr. Eissenberg ordered from you but you might not find out who ordered it.
He's made it very clear that he wants to get the units and carts at arms length. They don't cost him a lot relative to the other costs involved in one of his studies. And on thinking about it I think he's right to keep arm's length - when he gets positive results, as I think he will when he next does a related study, it will be very important for there to be no suggestion of impropriety. (The nay-sayers will be looking for anything they can find to criticize a study with positive results!)
I do think it a safe bet that he'll order from Vapor4Life if/when he does more studies since these are now the one device he has reason to believe will deliver - this way he'll avoid the criticisms which were made of his current study.
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