No, one of the legs is floating because of the cut trace on column 2. You don't need to solder it in, and you actually need to be really, really sure there is no chance of connection. Cut the trace on the board, even if you don't solder the pin in, and probably even if you cut the pin off of the pot before assembly. If it does connect, at best you'll waste a bunch of power. Or, you'll melt the pot. The worst case involves making your batteries very angry.
The 220 ohm resistor is there to keep VOAdjust from shorting to ground if you bottom out the pot. The datasheet actually says 240 ohms minimum, but 220 is a standard value in the 10% series. While they are probably being a bit conservative, you don't want to go any lower.
There probably isn't much point messing with the nominal pot value. The output voltage is well under what most of us would consider useful vaping voltage with just a couple hundred ohms (in addition to the safety resistor).
Edit: Just to be clear, by column 2, I mean the one on the right, under pin 2 of the chip. Forgetting to cut the trace as shown in column 4 (which is the 2nd column from the left side (where we normally start counting)) would be bad too, but with slightly less severe consequences, maybe nothing worse than letting the magic smoke out of your expensive regulator. Just be sure to cut them both, as shown.