How safe is 48mg e juice?
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Yea I would problably do the same but handling and vaping nic is different, I wear rubber gloves when chopping up Hot peppers because I've had figures start burning from them and wouldn't want my dogs or son to get them but eating them like in chili is diffrent
for example.... how much hard alcohol does it take for one to get blitzed?? 3 shots 7 shots 3/4 of a bottle? it all depends on how a body processes the "toxins" ( nic alcohol etc)... some people get nicsic on 6 mg/ml others can go as hi as 50mg/ml before feeling ill.....
I vaped 48mg juice for about the first month, to completely suppress the cravings for an analog. Then down to 36mg, and finally to 24mg, that seems to be optimal for me. No desire to reduce any further ... 
This was after 46 years of a 2 pack a day habit ...
This was after 46 years of a 2 pack a day habit ...
I just find it preposterous to say that vaping 48mg is like sucking on car exhaust - fundamentally these things are completely different... and carbon monoxide from car exhaust will kill you very fast.
also just because the LD50 is very likely to be 500mg doesn't mean you can't overdose much lower. Vaping 30ml of 48mg would be 1440 mg assuming 100% absorption. Assuming you vaped evenly over a 24 hour period to support your supposition of 30 ml in a day you would be taking 60mg/hour At the very least you would be feeling extremely nauseated by the end of the first hour and likely vomiting by the end of the second. I seriously doubt anyone could continue to vape at that rate without becoming ill (and thus stopping the fog machine) long before reaching a hospitalization dose.
Also I do not mind being associated with what I say. I've done sufficient research of my own to conclude that you will very likely vomit all over the place before being able to vape yourself to a dangerous dosage and if you keep on vaping after that you might have more intrinsic issues than nicotine poisoning. And thusly I will conclude that a study done on second generation vapor products recommended an increase to 50mg/ml
Nicotine absorption from electronic cigarette use: comparison between first and new-generation devices : Scientific Reports : Nature Publishing Group
"The use of 18 mg/ml nicotine-concentration liquid probably compromises ECs' effectiveness as smoking substitutes; this study supports the need for higher levels of nicotine-containing liquids (approximately 50 mg/ml) in order to deliver nicotine more effectively and approach the nicotine-delivery profile of tobacco cigarettes."
"In conclusion, new-generation EC devices delivering higher energy to the atomizer seem to be more effective than first-generation devices in nicotine delivery to the user and in reducing cravings for nicotine. However, both types of devices were significantly less effective in nicotine delivery compared to tobacco cigarettes when an 18 mg/ml nicotine containing liquid is used. It is reasonable to assume that nicotine levels in EC liquids should be considerably higher in order to improve their effectiveness in nicotine delivery, which is expected to make them more successful as smoking substitutes."
So considering OP wants to use 48 and this study recommends 50mg/ml I'll go ahead and say I'm okay with standing by my words and that if it helps OP quit awesome.
also just because the LD50 is very likely to be 500mg doesn't mean you can't overdose much lower. Vaping 30ml of 48mg would be 1440 mg assuming 100% absorption. Assuming you vaped evenly over a 24 hour period to support your supposition of 30 ml in a day you would be taking 60mg/hour At the very least you would be feeling extremely nauseated by the end of the first hour and likely vomiting by the end of the second. I seriously doubt anyone could continue to vape at that rate without becoming ill (and thus stopping the fog machine) long before reaching a hospitalization dose.
Also I do not mind being associated with what I say. I've done sufficient research of my own to conclude that you will very likely vomit all over the place before being able to vape yourself to a dangerous dosage and if you keep on vaping after that you might have more intrinsic issues than nicotine poisoning. And thusly I will conclude that a study done on second generation vapor products recommended an increase to 50mg/ml
Nicotine absorption from electronic cigarette use: comparison between first and new-generation devices : Scientific Reports : Nature Publishing Group
"The use of 18 mg/ml nicotine-concentration liquid probably compromises ECs' effectiveness as smoking substitutes; this study supports the need for higher levels of nicotine-containing liquids (approximately 50 mg/ml) in order to deliver nicotine more effectively and approach the nicotine-delivery profile of tobacco cigarettes."
"In conclusion, new-generation EC devices delivering higher energy to the atomizer seem to be more effective than first-generation devices in nicotine delivery to the user and in reducing cravings for nicotine. However, both types of devices were significantly less effective in nicotine delivery compared to tobacco cigarettes when an 18 mg/ml nicotine containing liquid is used. It is reasonable to assume that nicotine levels in EC liquids should be considerably higher in order to improve their effectiveness in nicotine delivery, which is expected to make them more successful as smoking substitutes."
So considering OP wants to use 48 and this study recommends 50mg/ml I'll go ahead and say I'm okay with standing by my words and that if it helps OP quit awesome.
I understand that but from a medical standpoint absorption though your lungs is pretty fast, again without solid hard evidence there is no data on it. I do know though suffering from sever allergic reactions to peppers that my "Epi pen" was replaced with an inhaler version that works just as fast. The skin is designed to keep out chemicals, liquids and bacteria from entering our body so if you look at it from that standpoint I'd be more afraid of inhaling it then getting it on me.
I routinely mix 100mg concentrate, rarely bother with gloves, and have never had any noticeable reaction. The concentrate goes straight from the measuring syringe into the mix bottle or beaker, with the required PG/VG. I don't drink the stuff, or intentionally smear it on my hands. Or inject it in my veins. I always mix near a sink and if I did get any on me I would wash it off immediately. A little reasonableness here, please!
I was a 3 PAD smoker, and I needed 24mg to quit. I am down to 12mg now but I chain vape by intent. If I wanted to vape less I would try upping it. But I enjoy it. I obviously have a high tolerance for nicotine after 40 years of heavy smoking. I never got more than a nice slightly dizzy "high", regardless of how much 24mg I vaped.
We are all different but if a few drops of 100mg on a finger caused anything more than a "nicotine high" and maybe a headache, I think we would read a lot more about it. A few anecdotal poorly reported stories of people going to emergency wards for OD on 100MG... well, it would be good to know how they managed that.
If you think you need gloves, use them. If you think 12mg is "strong" based on your reaction to vaping it, then surely you want to be more carefull because your tolerance is low. If you can't pull nic into a syringe and get it into a container without making a total mess, then surely use gloves. But this stuff is not arsenic. Actually it's just vitamin B3, but that is another story.
Edit: if mixing nic is new to you, then definitely use gloves until you are comfortable handling the stuff.
Pets are another story. When I did this in the same house as my cats, I was VERY careful to clean up and keep them away from the mixing operations. But that is a totally different matter.
I was a 3 PAD smoker, and I needed 24mg to quit. I am down to 12mg now but I chain vape by intent. If I wanted to vape less I would try upping it. But I enjoy it. I obviously have a high tolerance for nicotine after 40 years of heavy smoking. I never got more than a nice slightly dizzy "high", regardless of how much 24mg I vaped.
We are all different but if a few drops of 100mg on a finger caused anything more than a "nicotine high" and maybe a headache, I think we would read a lot more about it. A few anecdotal poorly reported stories of people going to emergency wards for OD on 100MG... well, it would be good to know how they managed that.
If you think you need gloves, use them. If you think 12mg is "strong" based on your reaction to vaping it, then surely you want to be more carefull because your tolerance is low. If you can't pull nic into a syringe and get it into a container without making a total mess, then surely use gloves. But this stuff is not arsenic. Actually it's just vitamin B3, but that is another story.
Edit: if mixing nic is new to you, then definitely use gloves until you are comfortable handling the stuff.
Pets are another story. When I did this in the same house as my cats, I was VERY careful to clean up and keep them away from the mixing operations. But that is a totally different matter.
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I agree with that, my wife was in the medical field before being taken over by Fibromyalgia, the tissue of the lungs are a lot more acceptable to nic than our skin but we can't compare get nic on our skin and inhaling it the same... take a nic patch for instance, with a nic patch your applying straight nic to the skin and will be more acceptable to irritation and illnesses if to much of it. With e juice with 48mg of nic is diluted with PG/VG and flavoring so while irratation from nic can occure there's no reason to extreme measures when filling a tank thats my opinion as for nic base I can't say because never messed with it
Actually that's not quite true when you buy 48mg/ml juice you are getting nic base mixed with vg/pg down to 48mg/ml so you are still handling a 48mg/ml liquid. but as the studies in previous posts show this is not a particularly dangerous amount as long as you don't chug it down or submerse your arm in it.
WOW-I started vaping just a short while ago and began with 24mg, I didn't even know you could get anything higher than that.
I have been lowering my nic content every few weeks whether I buy it or DIY it.
My juices range from 24 to zero and I honestly cannot tell much of a difference, maybe I don't need the nic-I just need to smoke something!!
Call me weird but one of my favorites is a 50/50 mix of 12mg and no flavor
I have been lowering my nic content every few weeks whether I buy it or DIY it.
My juices range from 24 to zero and I honestly cannot tell much of a difference, maybe I don't need the nic-I just need to smoke something!!
Call me weird but one of my favorites is a 50/50 mix of 12mg and no flavor
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