Maybe this is more encouraging
E-Cigarettes and Toxin Exposure | Annals of Internal Medicine | American College of Physicians
Here's an excerpt of the results to save folks time:
"The e-cigarette–only and NRT-only users had significantly lower metabolite levels for TSNAs (including the
carcinogenic metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol [NNAL]) and VOCs
(including metabolites of the toxins acrolein; acrylamide; acrylonitrile; 1,3-butadiene; and
ethylene oxide) than combustible cigarette–only, dual combustible cigarette–e-cigarette, or
dual combustible cigarette–NRT users. The e-cigarette–only users had significantly lower
NNAL levels than all other groups."
And there's this:
Evidence for harm reduction in COPD smokers who switch to electronic cigarettes
Here are the graphs of results to save folks time too:
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Personally, I'm more encouraged by results from actually, like using e cigarettes, and seeing improvements in both decreasing toxic metabolites measured in real people, and evidence of folks with significant lung disease (like lots of us ex-smokers around here likely have to one degree or another) improving with e cigarette use in comparison to smoking. In vitro tissue culture studies are certainly helpful when evaluating outside of actual clinical study (easier to do with cells in a dish than gather up a bunch of actual people and follow them over several years or have them keep coming back for tests of toxin levels, way cheaper too) but are limited to the difficulty in interpretation of cellular responses and correlation with the multiple cell types which make up our lungs (way more types than just the one in the culture dish).
I will also throw out for folks to consider when posting links to scientific articles, particularly when using specific testing techniques which may have both advantages as well as limitation, to recognize that the large majority of folks around here probably lack the knowledge or experience to critically analyze the studies presented, and therefore just work off the title of the article. That in and of itself can be misleading to forum readers unable to to place such published material within context.
Of course that is not meant for those with a medical, cell biology, physiology and/or toxicology background around here. Just sayin'.
True, nobody is saying that vaping isn't considerably safer than smoking.
What the in vitro tests do tell us though is that the liquids with flavorings damaged more cells than the control, which was just PG/VG.
Also, it showed that some flavorings did more damage than others.
Whether that makes much difference in real life is debatable though.