Does nicotine, or any of the other ingredients in most e-liquids, kill brain cells or stunt brain development over time?
Thanks!
Thanks!
Nicotine -- Effects on the Brain?
- Thread starter K.C.
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From Wikipedia:
By binding to nicotinic acetylcholine receptors, nicotine increases the levels of several neurotransmitters - acting as a sort of "volume control". It is thought that increased levels of dopamine in the reward circuits of the brain are responsible for the euphoria and relaxation and eventual addiction caused by nicotine consumption. Nicotine has a higher affinity for acetylcholine receptors in the brain than those in skeletal muscle, though at toxic doses it can induce contractions and respiratory paralysis. Nicotine's selectivity is thought to be due to a particular amino acid difference on these receptor subtypes.
tobacco smoke contains the monoamine oxidase inhibitors harman, norharman, anabasine, anatabine, and nornicotine. These compounds significantly decrease MAO activity in smokers. MAO enzymes break down monoaminergic neurotransmitters such as dopamine, norepinephrine, and serotonin.
Chronic nicotine exposure via tobacco smoking up-regulates alpha4beta2* nAChR in cerebellum and brainstem regions but not habenulopeduncular structures. Alpha4beta2 and alpha6beta2 receptors, present in the ventral tegmental area, play a crucial role in mediating the reinforcement effects of nicotine.
It think it says:
Nicotine makes you feel awake, satisfied, and stimulates your happy face.
Tobacco smoke (not vaping) also makes it so your body chemistry can't stimulate it's own happy face.
By binding to nicotinic acetylcholine receptors, nicotine increases the levels of several neurotransmitters - acting as a sort of "volume control". It is thought that increased levels of dopamine in the reward circuits of the brain are responsible for the euphoria and relaxation and eventual addiction caused by nicotine consumption. Nicotine has a higher affinity for acetylcholine receptors in the brain than those in skeletal muscle, though at toxic doses it can induce contractions and respiratory paralysis. Nicotine's selectivity is thought to be due to a particular amino acid difference on these receptor subtypes.
tobacco smoke contains the monoamine oxidase inhibitors harman, norharman, anabasine, anatabine, and nornicotine. These compounds significantly decrease MAO activity in smokers. MAO enzymes break down monoaminergic neurotransmitters such as dopamine, norepinephrine, and serotonin.
Chronic nicotine exposure via tobacco smoking up-regulates alpha4beta2* nAChR in cerebellum and brainstem regions but not habenulopeduncular structures. Alpha4beta2 and alpha6beta2 receptors, present in the ventral tegmental area, play a crucial role in mediating the reinforcement effects of nicotine.
It think it says:
Nicotine makes you feel awake, satisfied, and stimulates your happy face.
Tobacco smoke (not vaping) also makes it so your body chemistry can't stimulate it's own happy face.
ps long term exposure to tobacco smoke (not vaping) can harm your brain so that it can not recover and re-learn to stimulate it's own happy face again, ever...
Or in other words, long term smokers run the risk of permanently damaging the parts of the brain that regulate dopamine. This is not the result of nicotine consumption though, it's the result of tobacco smoking.
Or in other words, long term smokers run the risk of permanently damaging the parts of the brain that regulate dopamine. This is not the result of nicotine consumption though, it's the result of tobacco smoking.
Another chemical commonly found is Propylene Glycol (PG)
Read about it here:
http://www.e-cigarette-forum.com/forum/health-safety-e-smoking/2417-pg-safe.html
Read about it here:
http://www.e-cigarette-forum.com/forum/health-safety-e-smoking/2417-pg-safe.html
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