The last few times i have been around the forum, or been to a vape chat, all i can see and hear are people who are up in arms as someone classified nicotine as a narcodic. Well, to some extent they are true, and here is the information i have dug up on it (yes i was bored and thought i would make a post)
Scientific classification of Nicotine:
Bio-Avilabilty: 20-40% (oral)
Metabolism: Hepatic
Half-Life: 2hrs (20hrs active metabolic)
Formula: C10H14N2
Nicotine Molucule mass: 162.12g/mol
Density: 1.01g/cm2
Melt. Point: -79C (-100C)
Boiling Point: 247C (447F)
Flash Point: 95C (203F)
Ignition point: 224C (435F)
Behavior of Nicotine
Lower doses of nicotine (on average and on par as what is delieved via a single cigarette that constitutes 1mg) will act as a stimulate in all forms of known mamals. Higher does of nicotine introduced into the biological system around the 30mg to 60mg mark can be fatal.
Nictoine nicotine addiction has historically been one of the hardest addictions to break, while the pharmacological and behavioral characteristics that determine tobacco addiction are similar to those determining addiction to ...... and ........ In this context: Nicotine's mood-altering effects are different by report: in particular it is both a stimulant and a relaxant. First causing a release of glucose from the liver and epinephrine (adrenaline) from the adrenal medulla, it causes stimulation. Users report feelings of relaxation, sharpness, calmness, and alertness. Like any stimulant, it may very rarely cause the often catastrophically uncomfortable neuropsychiatric effect of akathisia. By reducing the appetite and raising the metabolism, some smokers may lose weight as a consequence.
Thus we have that though the comment of nictontine is similar to a drug, it is (though taken of the orignal context) very likely to be true.
Pharmacology
As nicotine enters the body, it is distributed quickly through the bloodstream and crosses the bloodbrain barrier reaching the brain within 1020 seconds after inhalation. The elimination half-life of nicotine in the body is around two hours.
The amount of nicotine absorbed by the body from smoking depends on many factors, including the types of tobacco, whether the smoke is inhaled, and whether a filter is used. For chewing tobacco, dipping tobacco, snus and snuff, which are held in the mouth between the lip and gum, or taken in the nose, the amount released into the body tends to be much greater than smoked tobacco. Nicotine is metabolized in the liver by cytochrome P450 enzymes (mostly CYP2A6, and also by CYP2B6). A major metabolite is cotinine
Pharmacodynamics
Nicotine acts on the nicotinic acetylcholine receptors, specifically the ganglion type nicotinic receptor and one CNS nicotinic receptor. The former is present in the adrenal medulla and elsewhere, while the latter is present in the central nervous system (CNS). In small concentrations, nicotine increases the activity of these receptors. Nicotine also has effects on a variety of other neurotransmitters through less direct mechanisms.
(Wonder if i should go talk to the FDA and run circles around them now?)
Scientific classification of Nicotine:
Bio-Avilabilty: 20-40% (oral)
Metabolism: Hepatic
Half-Life: 2hrs (20hrs active metabolic)
Formula: C10H14N2
Nicotine Molucule mass: 162.12g/mol
Density: 1.01g/cm2
Melt. Point: -79C (-100C)
Boiling Point: 247C (447F)
Flash Point: 95C (203F)
Ignition point: 224C (435F)
Behavior of Nicotine
Lower doses of nicotine (on average and on par as what is delieved via a single cigarette that constitutes 1mg) will act as a stimulate in all forms of known mamals. Higher does of nicotine introduced into the biological system around the 30mg to 60mg mark can be fatal.
Nictoine nicotine addiction has historically been one of the hardest addictions to break, while the pharmacological and behavioral characteristics that determine tobacco addiction are similar to those determining addiction to ...... and ........ In this context: Nicotine's mood-altering effects are different by report: in particular it is both a stimulant and a relaxant. First causing a release of glucose from the liver and epinephrine (adrenaline) from the adrenal medulla, it causes stimulation. Users report feelings of relaxation, sharpness, calmness, and alertness. Like any stimulant, it may very rarely cause the often catastrophically uncomfortable neuropsychiatric effect of akathisia. By reducing the appetite and raising the metabolism, some smokers may lose weight as a consequence.
Thus we have that though the comment of nictontine is similar to a drug, it is (though taken of the orignal context) very likely to be true.
Pharmacology
As nicotine enters the body, it is distributed quickly through the bloodstream and crosses the bloodbrain barrier reaching the brain within 1020 seconds after inhalation. The elimination half-life of nicotine in the body is around two hours.
The amount of nicotine absorbed by the body from smoking depends on many factors, including the types of tobacco, whether the smoke is inhaled, and whether a filter is used. For chewing tobacco, dipping tobacco, snus and snuff, which are held in the mouth between the lip and gum, or taken in the nose, the amount released into the body tends to be much greater than smoked tobacco. Nicotine is metabolized in the liver by cytochrome P450 enzymes (mostly CYP2A6, and also by CYP2B6). A major metabolite is cotinine
Pharmacodynamics
Nicotine acts on the nicotinic acetylcholine receptors, specifically the ganglion type nicotinic receptor and one CNS nicotinic receptor. The former is present in the adrenal medulla and elsewhere, while the latter is present in the central nervous system (CNS). In small concentrations, nicotine increases the activity of these receptors. Nicotine also has effects on a variety of other neurotransmitters through less direct mechanisms.
(Wonder if i should go talk to the FDA and run circles around them now?)
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