Other than they won't feel lonely since it's not a party issue. It's individual. They'd abandon the position if enough pressure was put on them. THR is way, way, way on the back pages as an issue. But HR is accepted for all other addictions and supported by Dem's.
I think the right has grabbed hold of it to grandstand civil liberties and "bigger gov't" (as if this isn't an example of "smaller gov't" gone wrong, i.e. lead by corporations). Ah well...
I still think the TPP chapter on tobacco is leading the end game. To my knowledge, that chapter has not been leaked. I looked for it. The most I could find was that it definitely existed and of course, tobacco and pharmaceuticals companies helped draft it. But it eliminates domestic sovereignty in areas = so many countries changing tobacco regulations at once. US courts fully support int'l trade agreement over domestic law.
Yup, the real divide is between the money/power vs most of us, and not with each other. I think that's critical to keep in mind. I would base everything on that core concept. I don't think anyone care what color that is.