I know someone who did not pursue a job offer because the company was a "smoke free" workplace. They made him an offer for employment but wanted to do nicotine testing as part of the pre-employment screening process, so he declined the offer. How would you guys handle this scenario or has anyone dealt with this? I don't really see the employer buying into the e-cig thing as a healthy alternative or as an excuse to having nicotine in your system. He is an e-cig smoker.

There are jobs where smoke breaks during the day are not feasible/possible (eg cleanroom work) but either you adapt or it becomes a performance issue. (If you are so stressed at the end of the day from not smoking that you can't do your job, then it isn't the right job for you..)