Dvap, your posts are terrific. I've followed you in the other threads. Chemistry aside for a moment, the only bottom line for me is blood nicotine level and per puff nicotine delivery.
When e-smoking can move my blood nicotine level to what I had as a former 30-a-day cigarette smoker .. whoopee. Until then, I'm nicotine deprived as an e-smoker and get what I need from snus, nasal snuff, and disssolvables used at the same time as I vape 36mg liquid.
I have to agree with this. I've been vaping 36-48 mg liquid for about 2 years and I still haven't quit smoking. It is so obvious in the morning when my chest feels like it's caving in, I smoke a cigarette, and I'm fine. It cannot be vaped away, period. It will go away with time of course, but that happens regardless of whether or not I vape.
I have never gotten a buzz off vaping. I've never gotten nauseous from vaping too much. My heart rate and blood pressure do not increase when I vape. It's damn obvious when I smoke too much. I don't get a buzz but I get a little shakey and slight nausea. I'll get a buzz if I haven't smoked in a day or two, even if I vaped the entire time. When I smoke my heart rate is consistently over 100 and my blood pressure is slightly high.
Vaping mimics smoking better than anything out there. I've tried the nicotine inhalers and I have to say, they suck. They don't feel like a cigarette at all, not to mention, they look like a tampon. They burn all the way down. There is no throat hit or fullness and no smoke/vapor. It's very unpleasant.
I believe that e cigs are a very powerful placebo for most people. Whether or not the nicotine is helping I believe it is debatable. If the nicotine does help, I don't think it helps much. I think the placebo effect is doing most of the work.
I also believe that people who started smoking when their brains were still developing or their mothers' smoked while pregnant will have a harder time quitting. Both happened in my case. It is already known that many drugs/chemicals can alter brain chemistry/genes, particularly in a developing brain. These people will probably need an extra kick in the ... that vaping can't seem to deliver right now. Those who have ADHD have a more difficult time with nicotine due to the dopamine action and lack of self-control. I have ADHD. I'm going to need something very close to the real thing.
I think that there are too many unknown variables to try to put a number on this right now. I'm almost positive that, for myself, I'm barely getting any nicotine and I'm certainly not getting the MAOI effect. There are a lot of factors that have to be taken into consideration: MAOI/WTA, comparison of blood levels/cardiovascular effects, long/short term effects on body/brain (fetus to adult), pre-existing conditions or conditions potentially caused by tobacco, genetics, heredity, etc. I'm no expert but I've read a lot of articles that point out some of these factors make people more likely to smoke, they smoke more, and/or it's harder for them to quit. That makes me think there is probably a little bit more to this than just nicotine and maybe even more than just MAOI/WTA.
I'm not saying e cigs are a bad thing. I love my e cig and I can no longer do without it. I'm much more likely to give it up than a cigarette though. It's amazing that so many have been able to use it to quit. I have only been able to use it to cut down, and not much (2 packs to 1 or 1 1/2). But...what if it could be more amazing? What if those of us who are having trouble could get the desired results as well? I honestly can't see anything wrong with trying to improve upon something that has so much potential.