How important is this? I ask this question both 1.) are analogs not sufficient and 2.) do they really need to be sourced from tobacco? Say for example we just want to add an MAOI. I've experimented with adding harmine to e-juice but I would need more subjects than myself to comment on its efficacy satisfying WTA cravings. Harmine is present in tobacco, but I'm not going to take the time to use it as a source when it's available for sale already isolated (you local laws may vary).
The large question I see when adding tobacco's alkaloids other than nicotine is 1.) the efficiency of their delivery and 2.) their natural quantities relative to nicotine.
Harmine is a relatively safe MAOI but it isn't something I would feel comfortable dispensing at unregarded doses
The MAOI activity of tobacco vis a vis it's addictiveness and efficacy in making some folks feel human is a fairly sound theory, but until and unless someone can come up with a mixture of non-tobacco derived compounds that does the trick for folks who must have the medicinal effects of tobacco, it's just a fairly sound theory.
The theory at work behind my extraction and purification of tobacco alkaloids is simply that which I've said many times, "Nothing is more like tobacco than tobacco". While the impressions of folks such as Hittman, Vaporer, Twisted Victor, Kurt, TropicalBob, and a couple others who have had the opportunity to use my WTA eliquid does not constitute "proof" of my theory that the tobacco alkaloid spread is the "magic bullet", their common experience of a deeply relaxing WTA vape certainly speaks to the anecdotal side of the question. If you give somebody something to use, and they find that it performs a certain desired function well, then that function has been satisfied, and that something is deemed "effective" by that person.
The bottom line effect that I observe is this, Users of the WTA eliquid that I've produced are crazy about the stuff. They find their cravings are satisfied, their usage drops, and they're feeling good. Twisted Victor is the "poster child" for this effect. He happily uses snus these days, but WTA was the first hope he had for feeling "normal", and indeed he felt normal when using it, progressing then onto the readily available snus which works in a very similar manner in providing WTA as does WTA eliquid.
Gawd.. I write geeky, don't I?
