yes
the more ohms the less wattage you are going to get (on a mech) and there is a point when the low power won't vaporize your
juice.
now on regulated devices it is the same, although you can get away with higher omhs as you can crank up the voltage or wattage but there is still a limit just don't know it for myself.
but if you are in the range it should work, you will notice in diminishing taste and vapor production once you get close to that limit but it isn't unsafe to cross it if that is what you are looking to find out