UK Trial on Nicotine-free E-Cigarettes

[Tom09]

trial purpose:

There are currently two sensorimotor replacement products which may be of benefit in smoking cessation: de-nicotinised cigarettes (denics) and electronic cigarettes (ECs), and the purpose of this project is to investigate whether these replacements can help to alleviate tobacco withdrawal symptoms in smokers, during a period of abstinence. This project will be separated into two studies, following the same design and procedures.
Study 1 will seek to confirm the importance of sensorimotor cues by comparing the efficacy of a nicotine-free EC in alleviating withdrawal symptoms, to a behavioural distraction tool (e.g. stress ball) which provides no smoking-related cues.
Study 2 will investigate whether sensorimotor replacements which are more proximal to smoking (i.e. Denics), will be more effective in alleviating withdrawal symptoms than a replacement which only delivers some of the conditioned sensorimotor cues (i.e. ECs).
We hypothesise that the EC will be more effective at reducing withdrawal symptoms compared to the stress ball in Study 1. In Study 2, it is hypothesised that the Denic will be more effective than the EC.

study group (McRobbie)

 

[Vocalek]

Wouldn't De-nicotinised cigarettes be more harmful, due to the fact that they contain the products of combustion?

 

[izabella]

de-nicotinised cigarettes

I don't know what those are. They have everything else in them that regular cigarettes have, except no nicotine? But they have all the other chemicals in them?

 

[emus]

Interesting trial.
Doubt if it's ALA sponsored.

Denics...hmmm.
I'd like to see the white napkin test first.
If fails white napkin test then I wonder about COPD.

I like the EC part.

I'll put my money on EC over Denics any day.

 

[Bill Godshall]

Vocalek inquired:

Wouldn't De-nicotinised cigarettes be more harmful, due to the fact that they contain the products of combustion?

Yes, no-nicotine cigarettes are just as hazardous as other cigarettes if/when they are smoked like other cigarettes.

Study 2 is looking to find out if no-nicotine cigarettes are "more effective in alleviating withdrawal symptoms" than e-cigarettes, and I suspect the researchers may find that cigarette smokers believe (after initial usage) that a no-nicotine cigarette alleviates withdrawal symptoms more effectively than an e-cigarette. But that will likely occur because the no-nicotine cigarette will taste very similar to their regular cigarette, and because they've never used an e-cigarette (especially a no nicotine e-cigarette) before.

 

[emus]

Vocalek inquired:



Yes, no-nicotine cigarettes are just as hazardous as other cigarettes if/when they are smoked like other cigarettes.

Study 2 is looking to find out if no-nicotine cigarettes are "more effective in alleviating withdrawal symptoms" than e-cigarettes, and I suspect the researchers may find that cigarette smokers believe (after initial usage) that a no-nicotine cigarette alleviates withdrawal symptoms more effectively than an e-cigarette. But that will likely occur because the no-nicotine cigarette will taste very similar to their regular cigarette, and because they've never used an e-cigarette (especially a no nicotine e-cigarette) before.

I'll still put my money on EC because Nonic likely won't provide TH.
Not sure everybody likes taste of analog that much.
Some eliquids taste great.