Nice post, Fernand, that you.
It is my impression from reading through a lot of very chemist-dominated threads (and understanding about 60% of it) that pH-regulating the juice to the point that some of the nicotine is bound in salts doesn't really affect the effect of the nicotine. The idea being that when the juice is heated the salts break up and the nicotine is released, so while the amount of free base nicotine in your atty or cart or tank might be less in a more acidic juice, once it is in your mouth in the form of vapour the nicotine content is the same as what you'd get from a juice with all free base nicotine.
At least that is my understanding of the speculations from the actual chemists, some of whom says they have been in contact with vendors who routinely acidify their liquids for better shelf life and to minimize smell (the salts don't oxidize, so no colourtint and no smell).
And it's maybe worth saying that anything but small departures from around a neutral or slightly basic pH is likely to affect nicotine absorption. Nicotine as a free base is what's best absorbed, and a more acidic juice, in addition to being irritating to throat/lungs, is going to contain more e.g. Nicotine Citrate instead.
It is my impression from reading through a lot of very chemist-dominated threads (and understanding about 60% of it) that pH-regulating the juice to the point that some of the nicotine is bound in salts doesn't really affect the effect of the nicotine. The idea being that when the juice is heated the salts break up and the nicotine is released, so while the amount of free base nicotine in your atty or cart or tank might be less in a more acidic juice, once it is in your mouth in the form of vapour the nicotine content is the same as what you'd get from a juice with all free base nicotine.
At least that is my understanding of the speculations from the actual chemists, some of whom says they have been in contact with vendors who routinely acidify their liquids for better shelf life and to minimize smell (the salts don't oxidize, so no colourtint and no smell).