I use gloves and syringes when I'm making base. I buy my nicotine at 100mg/ml and cut it down with PG. Easiest way I've found to do it was with a couple of small plastic containers. I think my wife got them at the dollar store. That saves me from having to twist a bottle around in order to reach the nicotine, and they have a lip on them that makes it easier to pour back into the bottle. And nicotine can absorb very quickly through your skin-on your hands particularly. Remember, the LD50 of pure nicotine is pretty low. Handle it like it's battery acid and you should be safe.