Just my 2 cents, but we all react differently to things. Case in point, my daughter (36) gets EXTREMELY depressed when on certain antibiotics and prescription pain relievers. She knows which ones to avoid, and will not accept a prescription for the ones she knows cause a reaction. If she gets anything new and it causes a reaction, she calls her doctor for a different prescription. Doctors have told me and her (this has been going on since she was in middle school, at least) that they have not heard of this kind of reaction, so now we just say she is allergic to certain meds. I, personally, think artificial sweeteners taste bitter, not sweet. Her throat starts closing up with artificial sweeteners. She recently, through trial and error, found that she is gluten sensitive. Even with things that she has no expectation of having gluten, she has had the stomach problems, etc., so we as a family avoid gluten. Some people do have "off the wall" reactions to things that most of the population can tolerate. It does seem strange, however, that the OP has not come back to this thread to comment on some of the suggestions, etc. Personally, if I were the OP, I would talk to my doctor, and experiment with different levels of PG, VG, and nicotine to try to get to the root of the problem. Since I do most of the ordering of our vaping supplies (we share living accommodations and expenses), when I see something on ECF that I think might affect either of us, I let her know so we can both monitor our reactions, and we can adjust things until we get to where we are happy and reaction free.