The worst is measuring in drops...which can change depending on your equipment, what you are using (VG and PG drops are very different sizes), and temperature.
The problem is most of us only have access to equipment that lets us measure amounts bigger than around 0.5mL with any accuracy.
I've been rolling my own since March and have yet to have a problem mixing with drops or syringes for larger quantities. Where problems surface is when folks share recipes and the receiver's equipment may not be the same. This is understood amongst us. Furthermore, taste is very subjective and the majority of recipes will need fine tuning to your tastes.
All my recipes have been fine tuned using my own calc and, it doesn't matter the qty I want to make, they always come out the same regardless of the amount mfrd. I use a flat standard of 22 drops/ml in my recipes, for everything. Now this may not be accurate for all liquids and I know that. The standard used is not important, what is, is using the same standard all the time.