And yes, I do wear nitrile gloves and eye protection when doing this. A spill needs to be cleaned up immediately and can get messy, and as a chemist, its just part of the ritual, and I feel naked, exposed and distracted without them. Had too many little spills and messes not to wear them. True, PG and VG slow dermal absorption compared to pure nic itself, and getting some on you and washing it off quickly will probably not have much of an effect, but if you are small and/or have very soft skin where it got on you, you could feel it even if you wash it off quickly. I don't like anecdotal stories of how people got it all over their hands and didn't feel anything. There are many people with compromised health, or are very small in size, who could well be strongly and negatively affected by skin exposure, and 100 mg nic is not water. And nic in the eye will burn a lot and go right to the brain.
The answer to the question "Should I REALLY wear gloves and eye protection?" is "Shut up and wear gloves and eye protection."
There, I said it.
Thank you I am glad you said this, I have wanted to for a bit now but was afraid to due to the posts here. I am small in stature with a compromised immune system, vape a low amount of nic daily and have a very negative reaction when I got 100mg nic on my skin. I was in the process of re-bottling and felt I was being very careful, wearing personal protection and did not know I had gotten any on myself until I became very flush, sweating, followed quickly by vomiting, tachycardia, dizziness ....not everyone can take a bath in this or wear clothes soaked in it for the day and be ok.