Not yet.
I've been picking away at it slowly, you can't just sit down for two hours and play Fallout 4. So I'm running
through the Uncharted series, done 1 and halfway through 2.
There is just no ammo in Fallout 4, I am always out of something, got two power suits now, one needs an arm and I can't build or find stuff for that yet. Everything now wants me to go to Diamond City so that must be the major center of all things useful. I just don't want to jump there yet as there is still parts of Zone 1 I need to explore. I imagine once I fall in with the Brotherhood of Steele things will get better.
Just looked at the Fallout4 Google Map and Diamond City is a fair ways into it and there is lots of stuff I need to pick up just in my area.
Huge game is Huge!