Are e-liquids poisonous?

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IceCreamMan

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IceCreamMan

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rurwin

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If you drink a bottle of eliquid, you'll be at least very ill. If you drink a bottle of whiskey, you'll also be at least very ill.

A drop of eliquid is perfectly safe, just as a sip of whiskey is. The amount you'll get from spitting droplets is much less than you'll be absorbing from the vapour anyway. It will be out of your body within a few hours; it doesn't build up.

The 30-60mg accepted lethal dose is about 2ml, about a tankful, two cartomisers or half a pack of cigarettes. It's based on very dodgy research, two amateurs back in 1856 took a dose, felt ill and estimated what it would take to kill them. But that number is quoted in all authoritative reference works. Anecdotal evidence from people who have accidentally, or on purpose, over-dosed on nicotine suggests the lethal dose is probably more like 1000mg. That's about 50ml of 18mg/ml eliquid. One of the symptoms of a nicotine over-dose is copious vomiting, so it's not easy to keep that dose down.

One two year-old is reported as dying from drinking eliquid. There are no other reports of any deaths. In fact I believe, although there are reports of people going to hospitals after drinking the stuff, there are no cases of any being detained over-night.

Because drinking the stuff is dangerous, it is marked as a poison. Used responsibly it is as safe as any other substance, and considerably safer than some. Colchicine for example, a popular treatment for gout, has a lethal dose as low as 7mg. 150ml of bleach could kill you. It's not just recognised poisons that are dangerous. A mere six pints of water might be fatal, and that's only about double what you might drink to stave off a hangover.
 

retired1

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Nicotine Propaganda

4. "Nicotine is highly toxic"

No, it is probably not much more toxic than some other normal dietary elements.

In October 2013, Prof Mayer of Graz showed that nicotine's toxicity has been greatly overstated; that there is zero evidence for the current LD50; that no one has ever died as a result of consuming a dose equivalent to the current LD50; and that people routinely survive consumption of doses many times the current LD50 with no ill effects to speak of.

This was the first-ever comprehensive review of the evidence supporting the current LD50; and as a result (as Mayer reports that there is none whatsoever), the LD50 will need to be adjusted upward by as much as a factor of 20 (in line with his research into what does constitute a proven fatal dose). Even so, it still only applies to certain delivery methods such as injection, because it has been demonstrated that people can ingest a very large amount of nicotine and suffer no lasting effects [4]; although apparently the abdominal pain at the time takes some beating - nicotine ingestion (swallowing it) triggers a vomit reflex in adults and the material is almost entirely expelled.

"Nicotine is a toxic material because if you swallow a lot, the prolonged vomiting to expel it, and the abdominal pain, are severe." This statement is true.
 

rurwin

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Wow, are you a kid or something?

Studies as recently as 2009 have supported the 30-60mg lethal dose figures, and this comes from multiple studies, not a single one obtained "in a questionable manner". Seems to me you're spreading a bit of propaganda yourself there.

See Disposition of Toxic Drugs and Chemicals in Man (8th ed.) published 2008 and/or Medical Toxicology (3rd ed.) ISDN 9780781728454.



You're probably referring to the paper written by Bernd Mayer who believes that the lethal doze should be updated to 500-1000mg, but his research is entirely based on dogs and even he admits that more clinical studies need to be done before changing the current standards.

Mayer does take these studies into account, and uses them to reach his 1000mg estimate:

Mayer said:
Several detailed reviews are available on fatal nicotine intoxications caused by either suicidal intent or accidents, latter mainly resulting from misusage of nicotine-containing solutions marketed as pesticides (Esser and Kühn 1933; Larson et al. 1961 ; Maehly and Bonnichsen 1963 ; Tiess and Nagel 1966 ; Hayes 1982 ; Corkery et al. 2010 ; Solarino et al. 2010). The postmortem data reviewed by Maehly and Bonnichsen (1963) and more recently by Corkery et al. (2010) and Solarino et al. (2010) revealed minimal nicotine blood levels of 2 mg/L, but rapid decline of blood nicotine after death (Sanchez et al. 1996) may have led to under-estimation of the actual lethal concentration in delayed autopsies.

Despite these uncertainties and the complex pharmacokinetics of nicotine (Hukkanen et al. 2005), a rough estimate of the amount of ingested nicotine from postmortem analyses of blood levels appears feasible. Smoking a cigarette results in uptake of approximately 2 mg of nicotine and gives rise to mean arterial plasma concentrations of about 0.03 mg/L (30ng/ml) (Gourlay and Benowitz 1997). Based on 20% oral bioavailability of nicotine (Hukkanen et al. 2005) and assuming linear kinetics, an oral dose of 60 mg would give rise to a plasma concentration of about 0.18 mg/L. The literature reports on fatal nicotine intoxications suggest that the lower limit of lethal nicotine blood concentrations is about 2 mg/L, corresponding to 4 mg/L plasma, a concentration that is around 20-fold higher than that caused by intake of 60 mg nicotine.

ETA: Meyar does not base any of his reasoning on dogs. He merely remarks that the number he comes up with agrees with the proven LD50 dose for dogs. (Shortly after the quoted paragraph.)
 
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zoiDman

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Still ignores the fact that a normal individual will immediately vomit the ingested eliquid.

The "ZOMG" it's POISON and it'll KILL YOU rhetoric really does need to be dialed back by all, including the idjits who insist on perpetuating the idea via the media.

I just hope that someone can vomit out all that Nicotine. And not Choke on their puke ala Led Zeppelin's John Bonham.
 

rurwin

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If 1,000mg is the Magic number, then that's about 35ml of 28mg e-Liquid.

Or about 20ml of 48mg Nicotine Base.

Or about 10ml of 100mg/ml nicotine base, which this board states is dangerously high, should be the maximum used by anyone and that only with great care.

It also affects children much more strongly since their body mass is much smaller than an adult. Even if the 500-1000mg dose is correct, it will correspond to a 50-100mg dose for a young child. If 30-60mg is correct, that's less than one cigarette.

Until more research is done, we should treat nicotine as if the lethal dose was 30-60mg, (a few drops of 100mg/ml,) because we are not qualified to decide otherwise. When I post about it, that is always the first number I quote, and I suggest others do likewise. It is fairly obvious to me, however, that it is wrong.
 
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anavidfan

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If it were as "poisonous" as they want you to believe, Id be dead. When I was getting into cartomizers and tanks I must have accidentally drank a few mls each time I messed up. I must have drank a few mls a couple times a day. Combined with spilling it all over me , some does get into the blood stream thru skin. At that time I was using 18mg juice. I would get a bit "over nic'd", shaky, trembles, nauseous, etc.
 

zoiDman

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Most people who Ingest a "Poisonous" substance Do Not Die.

And a Healthy Adult is much more likely just to feel Sick and have no Lasting Effects. But a Small Child may be Different. And could have Renal or Liver Problems.

The Long and the Short of it is Keep e-Liquids Secure and Away from Children or Pets.
 

StephenMulkey

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I have a French one, d'lice 6mg nic, coffee flavour- it doesn't have a skull sign.
Then I have an UK one 'shisha e-liquid' bought from Amazon -(Bluestar e-Liquids GB - Great Value e-Liquids Delivered Worldwide) - this is 0mg tobacco flavour, it does have a skull sign
Then I have diamond mist (http://www.diamondmist.co.uk/e-liquids.html) - coffee flavour 0mg, it also has a skull sign..
And I also have an italian made liqua 12mg (also with a skull)

I am now really confused!
With a 0 6 or 12mg you are perfectly safe. Most don't have a skull symbol on it, but the ones that do probably put it on all bottles. The best way to have your question answered though is to contact the vendor directly and ask them. Speaking for eliquids in general though you have nothing to worry about getting a little in your mouth. I have to say though you shouldn't really be getting it in your mouth. You might need to upgrade your device.
 

yzer

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Time for some common sense.

According to the American Association of Poison Control Centers there is an "uptick" in reports of nicotine poisoning.

E-Cigarette Devices and Liquid Nicotine

Poison centers are reporting a recent uptick in calls about exposures to e-cigarette devices and liquid nicotine.

Slightly more than half of these reported exposures have occurred in young children under the age of six. However, this is consistent with National Poison Data System exposures to all substances combined.


Notice that AAPCC states that children are no more likely to be poisoned by nicotine than any other poisonous substance.

AAPCC list the following common sense precautions if using nicoline e-lquids. Some of these precautions have been championed on ECF for years.

-Protect your skin when handling the products.
-Always keep e-cigarettes and liquid nicotine locked up and out of the reach of children.
-Follow the specific disposal instructions on the label.
-If you think someone has been exposed to an e-cigarette or liquid nicotine, call your local poison center at 1-800-222-1222 immediately.

AAPCC reports a 307% increase in nicotine poisoning reports from 2012 to 2013.

This is the latest annual report available from AAPCC.
https://aapcc.s3.amazonaws.com/pdfs/annual_reports/2012_NPDS_Annual_Report.pdf

These are the top 25 substances that caused poisonings in 2012 (from the 2012 report linked above).

aapccc.jpg
 
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Burnie

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Can Nicotine kill you, sure, but it will take quite a bit. "PURE Nicotine, 100%" (we use at most 3.6%, 36mg/ml) it takes 50 mg/kg (of 100% PURE Nicotine) to kill 50% of the rat test subjects (LD50), how much do you weigh, do the math. Do you need to use caution, Sure, but it would take a lot of even 100mg/ml to kill you. Here is the MSDS (or one of them)

http://www.sciencelab.com/msds.php?msdsId=9926222
Now don't freak out, this is talking about 100% PURE Nicotine, not 3.6%, 36mg/ml that we use.

Don't be scared of it, just use precautions. I handle dangerous chemicals everyday, (I own a pest control company), but I take precautions and know what I am doing. But 100mg/ml Nicotine (10% Nicotine) is nothing I worry about, just use care, and surly not once it is cut to 24 or 36 mg/ml (2.4% or 3.6%) or even lower.

Vape On
Burnie
:vapor:
 

J.R..

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With children, pets, and non smokers (non already exposed to nicotine) i understand the risk/keep it away from them.
But my question is- isn't the point to get the nicotine into your system? if you get sum on your hands, or in your mouth, whats the difference then breathing the vapor into your lungs being absorbed by your mouth, lungs, and nose?
 

yzer

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With children, pets, and non smokers (non already exposed to nicotine) i understand the risk/keep it away from them.
But my question is- isn't the point to get the nicotine into your system? if you get sum on your hands, or in your mouth, whats the difference then breathing the vapor into your lungs being absorbed by your mouth, lungs, and nose?
It depends on how much nicotine you get exposed to.

If you get vaping strength nicotine liquid on your hands then wash it off with soap and water. If you should suck some up due to a malfunctioning atomizer or bad vaping technique then spit it out and rinse your mouth with water. If you slather vaping strength nicotine liquid all over your body as an after shower moisturizer you might be looking forward to a ride with the EMTs.

I work with 100 mg nicotine once a year when I prepare nicotine base for the year. I wear disposable plastic gloves and eye protection when using it. I also work with it in a well-ventilated room.
 

mostlyclassics

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It does make one wonder how people are vaping 36mg nic?

I started vaping at 24 mg./ml., but it wasn't enough. I sought out some 36 mg./ml. e-liquids and vaped at that strength, three to four ml. per day, for about six months. Then I started tapering down and now vape four to five ml. per day at 16 mg./ml., which seems to be about right for me.

If you do the math, for about six months, I was vaping 108 to 144 mg. of Vitamin N per day. And now I'm vaping 64 to 80 mg. per day. I've been vaping for a bit over three years. You'll find similar consumption numbers quoted by tens of thousands of people here on ECF.

And those numbers should surely put to bed the notion that the LD50 of nicotine is 30 to 60 mg.!
 
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